Abstract #0682
GluCEST imaging of Tumor Protease Activity
Mohammad Haris 1,2 , Anup Singh 1 , Imran Mohammed 3 , Ranjit Ittyerah 4 , Kavindra Nath 4 , Ravi Prakash R Nanga 1 , Catherine Debrosse 1 , Feliks Kogan 1 , Kejia Cai 1,5 , Harish Poptani 4 , Damodar Reddy 1 , Hari Hariharan 1 , and Ravinder Reddy 1
1
CMROI, Radiology, University of
Pennsylvania, Philadelphia, Pennsylvania, United States,
2
Research
Branch, Sidra Medical and Research Center, Doha, Qatar,
3
Department
of Pharmacology and Institute for Translational Medicine
and Therapeutics, University of Pennsylvania,
Philadelphia, Pennsylvania, United States,
4
Molecular
Imaging, Radiology, University of Pennsylvania,
Philadelphia, Pennsylvania, United States,
5
CMRR
3T Research Program, University of Illinois at Chicago,
Chicago, IL, United States
We propose a noninvasive MRI method that is capable of
measuring expression of cathepsin proteases in tumors in
vivo. Degradation of L-poly glutamate by cathepsins in
to glutamate or smaller peptide fragments exposes amine
protons, which can be monitored through chemical
exchange saturation transfer (CEST) imaging. In the
current study, we have shown the feasibility of mapping
cathepsins in tumor cells line and rat model of brain
tumor using CEST imaging technique.
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