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Abstract #0679

Transperineal in-bore 3T MRI guided prostate biopsy in active surveillance patients: Higher prevalence of anteriorly located positive prostate cancer targets

Tobias Penzkofer 1,2 , Kemal Tuncali 1 , Fiona M Fennessy 1,3 , Junichi Tokuda 1 , Andriy Fedorov 1 , Sang-Eun Song 1 , Nobuhiko Hata 1 , and Clare M Tempany 1

1 Radiology, Brigham and Women's Hospital, Boston, MA, United States, 2 Diagnostic and Interventional Radiology, RWTH Aachen University Hospital, Aachen, Germany, 3 Radiology, Dana Farber Cancer Institute, Boston, MA, United States

Based on the known impact of prostate cancer localization within the gland on the success rate of guided prostate biopsy, we assessed the influence of target localization on positivity rate in a cohort of 20 patients in an active surveillance setting. Using in-bore transperineal MRI-guided prostate biopsy we found that anterior prostate gland targets have a significantly higher cancer yields than any other location in the gland when biopsied using this transperineal access, with a markedly lower number of cores compared to template mapping biopsy. This data could impact biopsy strategies and decision making in the active surveillance setting.

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