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Abstract #0670

Robust 2D Diffusion Weighted Chemical Shift Imaging (DW-CSI) of the human brain at 7T

Ece Ercan 1 , Aranee Techawiboonwong 2 , Maarten J. Versluis 1 , Andrew G. Webb 1 , and Itamar Ronen 1

1 C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 2 Electrical Engineering, Mahidol University, Nakornpathom, Thailand

2D Diffusion Weighted Chemical Shift (DW-CSI) Imaging is a challenging method which lacks robustness due to the multi-shot nature of the acquisition, combined with the low SNR and the relatively high gradient strength needed for adequate diffusion weighting of the slow diffusing metabolites. Here, we show for the first time a method that accounts for both amplitude and phase inter-shot fluctuations, and generates robust, reproducible and anatomically meaningful DW-CSI and metabolite ADC maps.

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