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Abstract #0655

High Resolution Non-Gadolinium CEMRA in Renal Failure: Initial Results in Pediatric Patients at 3.0T

J. Paul Finn 1 , Sarah N Khan 1 , Aarti Luhar 1 , Theodore Hall 1 , Stanislas Rapacchi 1 , Fei Han 1 , Peng Hu 1 , Yutaka Natsuaki 2 , and Isidro Salusky 3

1 Radiology, UCLA, Los Angeles, California, United States, 2 Siemens Healthcare, California, United States, 3 Nephrology, UCLA, California, United States

Purpose: We report our initial findings with ferumoxytol for non-Gd CEMRA at 3.0T in children with renal failure. Methods: 9 patients aged 6 days to 14 years were studied on a Siemens TIM Trio system. Multiple CEMRA phases were acquired up to 30 minutes following injection and measurements of SNR and CNR in the thoracic aorta and inferior vena cava (IVC) were recorded at each phase. Phantom measurements of T1 and T2* relaxivity were made at 3.0T. Results: The T1 relaxivity was 9.0 mM-1s-1 and the T2 relaxivity was 90 mM-1s-1. CNR measurements in patients confirmed that the intravascular signal in the ferumoxytol group remained high and stable to the last measurements, up to 35 minutes post injection, whereas the signal in the control group fell off with time. Conclusion and Discussion: Initial results with ferumoxytol are highly encouraging for CEMRA in children with renal failure.

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