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Abstract #0643

Whole brain fMRI in 370ms: exploring the benefits of high temporal resolution 3D-EPI-CAIPI

Mayur Narsude 1,2 , Daniel Gallichan 3 , Wietske van der Zwaag 3 , Rolf Gruetter 3 , and Jose Marques 3

1 LIFMET, EPFL, Lausanne, Vaud, Switzerland, 2 University of Lausanne, Lausanne, Vaud, Switzerland, 3 CIBM, EPFL, Lausanne, Vaud, Switzerland

This study aimed to demonstrate benefit of highly accelerated 3D-EPI-CAIPI wholebrain fMRI, particularly the ability to filter out respiratory and cardiac noise. Thanks to the use of 3D-EPI-CAIPI sampling patterns, it was possible obtain a 3 and 8 fold increases in temporal resolution in respect to un-accelerated 3D-EPI with only mild g-factor penalty. Temporal SNR per unit of time of the 8-fold accelerated data was ~62% and ~26% higher than un-accelerated and 3-fold accelerated data respectively. Better physiological signals filtering with higher sampling rates resulted in higher statistical significance for resting state networks found via Independent Component Analysis.

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