Abstract #0636
Using MR frequency shifts to differentiate MS lesion pathologies
Vanessa Wiggermann 1,2 , Samantha Y.Y. Tan 3 , Enedino Hernndez Torres 1,4 , David K.B. Li 1,4 , Alex L. MacKay 2,4 , Irene M. Vavasour 1,4 , Nicholas Seneca 5 , David Leppert 5 , Shannon Kolind 4,6 , Anthony Traboulsee 4,6 , and Alexander Rauscher 1,4
1
Radiology, University of British Columbia,
Vancouver, BC, Canada,
2
Physics
and Astronomy, University of British Columbia,
Vancouver, BC, Canada,
3
Science, University of
British Columbia, Vancouver, BC, Canada,
4
UBC
MRI Research Centre, Vancouver, BC, Canada,
5
F.
Hoffmann-La Roche Ltd., Basel, Switzerland,
6
Neurology,
University of British Columbia, Vancouver, BC, Canada
Recent studies have exploited MR frequency shift mapping
as a high-resolution tool to monitor changes in MS
lesions. However, the origin of the observed changes in
MR frequency is not yet fully understood. Here, we
compared frequency shift imaging in 25 patients with two
myelin sensitive MR techniques, magnetization transfer
and myelin water imaging. Frequency shifts between
different lesions types differed greatly and variability
of frequency shifts within lesion types suggests that MR
frequency aids in characterizing lesions at different
stages of their development.
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