Abstract #0634
In vivo quantification of SPIO nanoparticles for cell labeling based on MR phase gradient images
Luning Wang 1 , William Potter 2 , and Qun Zhao 1
1
Department of Physics and Astronomy,
University of Georgia, Athens, GA, United States,
2
Laboratory
of Plasma Studies, Cornell University, Ithaca, NY,
United States
Along with the development of modern imaging
technologies, contrast agents play increasingly
important roles in both clinical applications and
scientific researches. Super-paramagnetic iron oxide
(SPIO) nanoparticle, a negative contrast agent, has been
extensively used in magnetic resonance imaging (MRI),
such as in vivo labeling and tracking of cells. However,
there still remain many challenges, such as in vivo
quantification of SPIO nanoparticles. In this work, a
novel MR phase gradient based method was proposed to
quantify the SPIO nanoparticles. As a calibration, a
phantom experiment using known concentrations (50, 75,
100, and 125 g/ml) of SPIO was first conducted to
verify the proposed quantification method. In a
following in vivo experiment, C6 glioma cells labeled
with SPIO nanoparticles were implanted into flanks of
four mice, which were scanned 1 to 3 days post-injection
for in vivo quantification of SPIO concentration. The
results showed that the concentration of SPIO
nanoparticles can be determined in both phantom and in
vivo experiments using the developed MR phase gradients
approach.
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