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Abstract #0607

On The Role of Physiological Fluctuations in Quantitative Gradient Echo MRI

Jie Wen 1 , Anne H. Cross 2 , and Dmitriy A. Yablonskiy 1

1 Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, United States, 2 Neurology, Washington University in St. Louis, St. Louis, MO, United States

Physiological fluctuations in biological tissues adversely affect MR images. In this abstract, a navigator- and a keyhole-based methods are used to reduce physiologically-induced artifacts. We study brains in normal subjects and subjects with multiple sclerosis and demonstrate that employed strategies substantially reduce the width of the R2*=1/T2* distribution within a human brain and provide significant improvement in quantifying tissue damage in multiple sclerosis. We also show improvement in the quality of GEPCI, SWI and QSM images. These correcting strategies greatly improve the reliability of quantitative gradient echo MRI techniques.

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