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Abstract #0599

Which parameters are optimal? - A comprehensive numerical analysis of background phase correction with SHARP

Ferdinand Schweser 1 , PĪ¹nar Senay zbay 2,3 , Andreas Deistung 1 , Edsel Daniel Peres Gomez 1 , Xiang Feng 1 , Daniel Nanz 2 , and Jrgen R Reichenbach 1

1 Medical Physics Group, Institute of Diagnostic and Interventional Radiology I, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany, 2 Department of Radiology, University Hospital Zurich, Zurich, Switzerland, 3 Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland

Sophisticated harmonic artifact reduction for phase data (SHARP) is regarded as one of the most important techniques in the area of background correction for QSM. The influence of the SHARP parameters has not been investigated in detail so far and they are usually chosen empirically, which may have serious consequences for the comparability of studies relying on SHARP processed phase images. We performed a comprehensive analysis of the impact of different parameter choices on the resulting images and propose a universal definition of the regularization parameter that does not depend on the spherical radius or on the image resolution.

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