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Abstract #0592

Serial perfusion imaging using arterial spin labeling in acute ischemic stroke

George William John Harston 1 , Thomas Okell 2 , Fintan Sheerin 3 , Martino Cellerini 3 , Stephen Payne 4 , Peter Jezzard 2 , Michael Chappell 4 , and James Kennedy 1

1 Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom, 2 Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, Oxfordshire, United Kingdom, 3 Oxford University Hospitals NHS Trust, Oxford, Oxfordshire, United Kingdom, 4 Department of Engineering Science, University of Oxford, Oxford, Oxfordshire, United Kingdom

Hypoperfusion underlies the pathophysiology of ischemic stroke and as such has been used extensively to identify tissue at risk of infarction. However, presenting perfusion imaging has not been successfully used to select patients for treatment. In this observational cohort study patients with large volume ischemic stroke were scanned serially with quantitative arterial spin labeling perfusion imaging to better understand the natural history of absolute perfusion measurements and the dynamics of cerebral blood flow over the first hours and days following a stroke. A marked individual and temporal heterogeneity of cerebral blood flow was observed.

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