Abstract #0584
Subcortical Auditory Information Processing after Bilateral Auditory Cortex Ablation
Patrick P. Gao 1,2 , Shu-Juan Fan 1,2 , Jevin W. Zhang 1,2 , Iris Y. Zhou 1,2 , Joe S. Cheng 1,2 , Yuqi Deng 2 , Dan H. Sanes 3 , and Ed X. Wu 1,2
1
Laboratory of Biomedical Imaging and Signal
Processing, The University of Hong Kong, Hong Kong,
HKSAR, China,
2
Department
of Electrical and Electronic Engineering, The University
of Hong Kong, Hong Kong, HKSAR, China,
3
Department
of Biology, New York University, New York, NY, United
States
Descending projections from cerebral cortex to
subcortical nuclei are among the largest pathways in the
brain, suggesting that they are important for
subcortical processing. In the auditory system, the
cortical output targets multiple subcortical nuclei.
However, compared with the ascending pathways, the
functional roles of these corticofugal projections are
poorly understood. Non-invasive fMRI is well suited to
investigating this question because it can assess
activities in multiple nuclei simultaneously. In this
study, bSSFP fMRI was applied to study the effect of
bilateral auditory cortex ablation on the responses to
sound pressure level (SPL) change in low subcortical
target nuclei.
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