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Abstract #0578

Laminar-resolution BOLD and CBV fMRI responding to layer-specific neural modulations in the olfactory bulb

Alexander Poplawsky 1 , Mitsuhiro Fukuda 1 , Xiaopeng Zong 2 , and Seong-Gi Kim 1,3

1 Radiology, University of Pittsburgh, Pittsburgh, PA, United States, 2 Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC, United States, 3 Biological Sciences, Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), SKKU, Suwon, Korea

We used high-resolution fMRI in the olfactory bulb model to examine whether hemodynamic responses are regulated at the laminar level. Odor and micro-stimulation of the lateral olfactory tract (LOT) were used to preferentially evoke activity in different bulb layers. We found different, neural-specific laminar activation patterns for each individual stimulation using CBV fMRI, but not BOLD. Specifically, for CBV, a ring-like activation was reproducibly observed only in middle layers (~200 m thick) following LOT stimulation that corresponds with the location of evoked neural activity. Our data provide definitive evidence that the hemodynamic response is regulated at the laminar level.

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