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Abstract #0571

MRS and diffusion MRI of the spinal cord in Friedreichs Ataxia

Pierre-Gilles Henry 1 , Dinesh Deelchand 1 , Isabelle Iltis 1 , Diane Hutter 1 , Khalaf O Bushara 1 , Gulin Oz 1 , and Christophe Lenglet 1

1 Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States

We measured 1 H MR spectra and acquired diffusion MRI data of the spinal cord in patients with Friedreichs Ataxia and control subjects at 3T. With 1 H MRS, we observed a 40% decrease in NAA and 46% increase in myo-inositol concentrations in the spinal cord of patients compared to controls, reflecting neuronal degeneration and gliosis, respectively. With diffusion, we observed a decrease in fractional anisotropy of the spinal cord, as well as alteration of the nerve roots. These findings may be useful to monitor disease progression and assess therapeutic efficacy in prospective clinical trials.

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