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Abstract #0530

Vascular Fingerprinting in Rat Brain Tumors

Benjamin Lemasson 1,2 , Nicolas Pannetier 3,4 , Rgine Farion 1,2 , Emmanuel Barbier 1,2 , Norbert Schuff 3,4 , Michael Moseley 5 , Greg Zaharchuk 5 , and Thomas Christen 5

1 U836, Iserm, Grenoble, France, 2 Grenoble Institut des Neurosciences, Universit Joseph Fourier, Grenoble, France, 3 Va medical center, Centre for neurodegenerative des eases, San Francisco, CA, United States, 4 University of California San Francisco, Department of Radiology and Biomedical Imaging, San Francisco, CA, United States, 5 Stanford University, Department of Radiology, Stanford, CA, United States

In this study, we tested the vascular fingerprinting approach in 8 rats bearing brain tumors. This recent method compares in vivo MR signal time evolutions to a dictionary of curves obtained with numerical simulations and creates maps of microvascular characteristics. We obtained good correlations with more conventional MR methods: steady-state susceptibility contrast imaging for blood volume mapping, Vessel Size Imaging and multiparametric quantitative BOLD imaging for blood oxygen saturation measurements. In two rats, high spatial resolution maps were obtained and compared to pimonidazole staining, a histological marker of tissue hypoxia.

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