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Abstract #0514

Hemodynamic Evaluation of Cerebral Arteriovenous Malformations with Combined 4D Flow and Perfusion MRI

Can Wu 1 , Timothy Carroll 1,2 , Sameer Ansari 2,3 , Amir Honarmand 2,3 , Parmede Vakil 2 , Michael Hurley 2,3 , Bernard Bendok 2,3 , James Carr 2 , and Michael Markl 1,2

1 Biomedical Engineering, Northwestern University, Chicago, IL, United States, 2 Radiology, Northwestern University, Chicago, IL, United States, 3 Neurological Surgery, Northwestern University, Chicago, IL, United States

4D flow and perfusion MRI were combined to quantitatively evaluate macro- and microvascular hemodynamics in cerebral arteriovenous malformations (AVMs), investigate the influence of Spetzler-Martin grade on AVM hemodynamics, and identify potential relationships between changes in macro- and microvascular flow and perfusion. The results demonstrated the influence of Spetzler-Martin grade on AVM hemodynamics in the feeding arteries, draining veins, and the straight sinus. In addition, we could identify significant relationships between large vessel flow and perfusion ratios. These findings demonstrate the potential of our imaging protocol for the comprehensive characterization of the impact of AVMs on macro- and microvascular hemodynamics.

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