Meeting Banner
Abstract #0506

MRI Measures of Cortical Bone Water Concentration: Dependence on Age and Pore Volume Fraction

Alan C. Seifert 1 , Cheng Li 1 , Hamidreza Saligheh Rad 1 , Chamith S. Rajapakse 1 , Wenli Sun 1 , Shing Chun Benny Lam 1 , and Felix W. Wehrli 1

1 Radiology, University of Pennsylvania, Philadelphia, PA, United States

Increased cortical porosity is a major cause of impaired strength of osteoporotic bone. Ultrashort echo-time MRI can detect short-T2 components in cortical bone and enables measurement of bulk bone water content (BWC). The suppression ratio (SR, ratio of signal without and with long-T2 suppression) may better reflect bone porosity. BWC is quantified in 72 humans and SR in 40 humans and 13 bone specimens, and these measurements are compared to x-ray-based modalities. Although SR is not an absolute measurement of pore volume fraction, SR is more highly correlated with age and porosity than pQCT mineral density or BWC.

This abstract and the presentation materials are available to members only; a login is required.

Join Here