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Abstract #0495

Hypoperfusion signature in healthy subjects in risk of developing Alzheimer's Disease

Pablo Garcia-Polo 1,2 , Virginia Mato 1,3 , Daniel Garcia-Frank 1,4 , Norberto Malpica 1 , Juan Alvarez-Linera 5 , and Juan Antonio Hernandez-Tamames 2,3

1 LAIMBIO-DTE, Universidad Rey Juan Carlos, Mostoles, Madrid, Spain, 2 Center for Biomedical Technology U.P.M., Pozuelo de Alarcon, Madrid, Spain, 3 Center for Alzheimer's Disease Queen Sofia Foundation CIEN Foundation, Madrid, Madrid, Spain, 4 IdiPAZ, Madrid, Spain, 5 Hospital Ruber Internacional, Madrid, Spain

This work analyses structural and physiological features in a healthy population (25 subjects, PAD group) in risk of developing Alzheimer's disease (left and right hippocampus mean-2std.) the asl technique provides perfusion maps that, after normalization and partial volume effect correction steps, are studied through a two-sample t-test (25 subjects control group). also, segmented 3dt1w images with vbm-dartel. pad, as expected, suffer from grey matter loss in both hippocampi and, additionally, hypoperfusion hippocampi, amygdala entorhinal cortex. we propose to include studies, more sensitive than structural vbm, standard research criteria for early diagnosis of ad.

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