Meeting Banner
Abstract #0488

Regional correlation between pCASL perfusion and PiB-PET in familial Alzheimer's disease

Lirong Yan 1 , Collin Liu 2 , Koon-Pong Wong 1 , Sung-Cheng Huang 1 , David Wharton 1 , John Ringman 1,3 , and Danny JJ Wang 1

1 University of California Los Angeles, Los Angeles, CA, United States, 2 University of South California, CA, United States, 3 Mary S. Easton Center for Alzheimer's Disease Research, University of California Los Angeles, CA, United States

The purpose of this study is to investigate the relationship between pseudo-continuous ASL (pCASL) perfusion and the parameters of relative perfusion (R1) and tracer distribution volume ratio (DVR) derived from PiB-PET in 25 familial Alzheimers disease related subjects. The spatial patterns between pCASL CBF and PiB-PET R1 are highly consistent with significant voxel-wise correlations, whereas the correlation between pCASL perfusion and PiB-PET DVR is negative across subjects. Our study supports the validity of both pCASL and PiB-PET as imaging markers of Alzheimers disease.

This abstract and the presentation materials are available to members only; a login is required.

Join Here