Abstract #0488
Regional correlation between pCASL perfusion and PiB-PET in familial Alzheimer's disease
Lirong Yan 1 , Collin Liu 2 , Koon-Pong Wong 1 , Sung-Cheng Huang 1 , David Wharton 1 , John Ringman 1,3 , and Danny JJ Wang 1
1
University of California Los Angeles, Los
Angeles, CA, United States,
2
University
of South California, CA, United States,
3
Mary
S. Easton Center for Alzheimer's Disease Research,
University of California Los Angeles, CA, United States
The purpose of this study is to investigate the
relationship between pseudo-continuous ASL (pCASL)
perfusion and the parameters of relative perfusion (R1)
and tracer distribution volume ratio (DVR) derived from
PiB-PET in 25 familial Alzheimers disease related
subjects. The spatial patterns between pCASL CBF and
PiB-PET R1 are highly consistent with significant
voxel-wise correlations, whereas the correlation between
pCASL perfusion and PiB-PET DVR is negative across
subjects. Our study supports the validity of both pCASL
and PiB-PET as imaging markers of Alzheimers disease.
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