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Abstract #0484

Detection of Metabolite Changes in Response to a Varying Visual Stimulation Paradigm Using Short TE 1 H MRS at 7T

Ralf Mekle 1 , Simone Kuehn 2 , Harald Pfeiffer 1 , Florian Schubert 1 , and Bernd Ittermann 1

1 Medical Physics, Physikalisch-Technische Bundesanstalt, Berlin, Germany, 2 Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany

The goal of this study was to detect differences in steady-state metabolite levels in response to a varying stimulation paradigm in the right human visual cortex using short TE 1 H MRS methodology at 7T. Instead of a strict on/off paradigm, where global physiologic effects might adversely influence MRS data acquisition, a modified stimulation condition not affecting the target voxel was employed as baseline. Nineteen metabolites were reliably quantified. A reduction of the neurotransmitter GABA and an increase of lactate were observed as the only significant effects. Differences with previous studies were attributed to the modified experimental conditions.

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