Abstract #0482
1H-MRS study in investigating the effect of dioscorea modified pill to the cognitive impairment of patients with VCIND
Jun Chen 1 , Jinhuan Liu 1 , Zihu Tan 2 , Qiong Yang 2 , Hanchao Lan 2 , Yilin Zhao 1 , Dongjie Huang 1 , Qizhong Xu 1 , and Liang Zhang 1
1
Department of Radiology, Renmin Hospital of
Wuhan University, Wuhan, Hubei Province, China,
2
Department
of Geriatrics, Hubei Hospital of Traditional Chinese
Medicine, Wuhan, Hubei Province, China
Vascular Cognitive Impairment No Dementia (VCIND) is
introduced to identify the earliest stage of cognitive
decline associated with vascular disease, which does not
meet dementia criteria but with an increased risk of
death and institutionalization1. Early detection of
VCIND has significant clinical implications for a valid
prognosis and treatement2. Proton magnetic resonance
spectroscopy (1H-MRS) has been proved useful in
investigating neurodegenerative diseases3. In this
study, the therapeutic effect of Dioscorea modified pill
and Aricept to VCIND patients was evaluated using brain
1H-MRS, mini-mental state examination (MMSE), clinical
dementia rating (CDR) and Montreal Cognitive Assessment
(MoCA) simultaneously and the relationship of these
measurements was investigated as well.
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