Abstract #0474
First clinical experience using fluorine-19 MRI to track immunotherapeutic dendritic cells in colorectal cancer patients
Eric T Ahrens 1 , Anthony Balducci 2 , Brooke Helfer 2 , Amy Wesa 2 , Charles O'Hanlon 2 , Claudiu Schirda 3 , David Bartlett 4 , and Pawel Kalinski 4
1
Radiology, University of California at San
Diego, La Jolla, CA, United States,
2
Celsense,
Inc., Pittsburgh, PA, United States,
3
Radiology,
University of Pittsburgh, Pittsburgh, PA, United States,
4
Surgical
Oncology, University of Pittsburgh, Pittsburgh, PA,
United States
Cell therapies, such as those employing immune or stem
cells, can benefit from non-invasive imaging to
visualize cells following transfer into the patient. We
described the first clinical use of a fluorine-19 MRI
tracer agent designed for MRI cell tracking. We labeled
autologous immunotherapeutic dendritic cells (DCs) with
a perfluorocarbon (PFC) tracer agent ex vivo. Labeled
DCs were inoculated into colorectal cancer patients.
Cells were detected using a 3T scanner using 19F
MRI/MRS. Clinical 19F-based cell tracking is feasible
and provides unambiguous information about the cell
location, with no background signal, and can be used to
quantify cells in situ.
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