GABA, glutamate and intellectual ability
Anouk Marsman 1 , Rene C.W. Mandl 1 , Dennis W.J. Klomp 2 , Vincent O. Boer 2 , Anna Andreychenko 3 , Wiepke Cahn 1 , Rene S. Kahn 1 , Peter R. Luijten 2 , and Hilleke E. Hulshoff Pol 1
Psychiatry, University Medical Center
Utrecht, Utrecht, Netherlands,
University Medical Center Utrecht, Utrecht, Netherlands,
University Medical Center Utrecht, Utrecht, Netherlands
Minimizing energy resources may be beneficial to
intelligence and a combination of higher GABA and lower
glutamate (Glu) levels suggest a more efficient energy
use. Performing 1H-MRS at an ultra-high field strength
of 7T results in increased sensitivity and spectral
resolution, which are particularly important when
measuring Glu and GABA. Using 7T 1H-MRS, we found that a
higher Working Memory Index (an aspect of intelligence)
was associated with a significantly higher GABA/Glu
ratio in the occipital cortex in healthy individuals.
This suggests that individuals with a higher intelligent
working memory performance make more efficient use of
their brains energy resources.
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