Abstract #0442
Resting-state cerebral blood flow and functional connectivity in focal epilepsy as assessed by arterial spin labeling
Silvia Francesca Storti 1 , Ilaria Boscolo Galazzo 1 , Alessandra Del Felice 1 , Francesca Pizzini 2 , Chiara Arcaro 1 , Emanuela Formaggio 3 , Roberto Mai 4 , Alberto Beltramello 2 , and Paolo Manganotti 1,3
1
Department of Neurological and Movement
Sciences, University of Verona, Verona, Italy,
2
Department
of Neuroradiology, AOUI of Verona, University of Verona,
Verona, Italy,
3
Department
of Neurophysiology, Foundation IRCCS San Camillo
Hospital, Venice, Italy,
4
Epilepsy
Surgery Center, Niguarda Hospital, Milan, Italy
Arterial spin labeling can be very useful for the
detection of perfusion changes in drug-resistant focal
epilepsy. In order to identify regions related to the
epileptic focus, quantification of CBF and a statistical
analysis were computed in each patient and compared with
a template of normal perfusion. A seed-driven
connectivity was also used to identify networks regions
that are differently organized in epileptic patients
compared to healthy subjects. The investigation allowed
us to correctly identify the epileptogenic zone in
patients, in whom the results were confirmed by surgical
resection and subsequent seizure freedom.
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