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Abstract #0442

Resting-state cerebral blood flow and functional connectivity in focal epilepsy as assessed by arterial spin labeling

Silvia Francesca Storti 1 , Ilaria Boscolo Galazzo 1 , Alessandra Del Felice 1 , Francesca Pizzini 2 , Chiara Arcaro 1 , Emanuela Formaggio 3 , Roberto Mai 4 , Alberto Beltramello 2 , and Paolo Manganotti 1,3

1 Department of Neurological and Movement Sciences, University of Verona, Verona, Italy, 2 Department of Neuroradiology, AOUI of Verona, University of Verona, Verona, Italy, 3 Department of Neurophysiology, Foundation IRCCS San Camillo Hospital, Venice, Italy, 4 Epilepsy Surgery Center, Niguarda Hospital, Milan, Italy

Arterial spin labeling can be very useful for the detection of perfusion changes in drug-resistant focal epilepsy. In order to identify regions related to the epileptic focus, quantification of CBF and a statistical analysis were computed in each patient and compared with a template of normal perfusion. A seed-driven connectivity was also used to identify networks regions that are differently organized in epileptic patients compared to healthy subjects. The investigation allowed us to correctly identify the epileptogenic zone in patients, in whom the results were confirmed by surgical resection and subsequent seizure freedom.

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