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Abstract #0435

Complete functional assessment of the mouse heart with one-minute acquisition

Guido Buonincontri 1 , Carmen Methner 2 , Thomas Krieg 2 , T Adrian Carpenter 1 , and Stephen J Sawiak 1,3

1 Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom, 2 Department of Medicine, University of Cambridge, Cambridge, United Kingdom, 3 Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom

Long scan duration limits the usage of cine MRI methods in mice. We employed spatiotemporal compressed sensing and parallel imaging to accelerate retrospectively-gated cine MRI of mouse hearts. We found that the scan time for the whole heart could be reduced to one minute when using radial sampling. The accuracy in the estimation of left and right ventricular volumes was preserved for all tested subjects. This method can be used to perform fast and accurate functional MRI exams in mice.

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