Meeting Banner
Abstract #0388

Unravel Neurochemical Contributions to Hemodynamic Responses using Simultaneous PET/MRI

Hsiao-Ying Wey 1 , Jacob M Hooker 1 , Bruce R Rosen 1 , and Joseph B Mandeville 1

1 A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States

Simultaneous PET/fMRI offers the unique opportunity to relate neurochemical events to the functional changes underlying neural activity. In this study, we present simultaneous PET/fMRI study with pharmacological challenges given to nonhuman primates to determine the relationship between opioid receptor occupancy, dopamine release, and changes in CBV. CBV-fMRI shows dose-response to opioid agonist challenges. PET and fMRI demonstrated concurrent signal changes overlapping in the basal forebrain, such as the caudate, putamen, and nucleus accumbens (NAc). In addition, the temporal response of dopamine release matches a fast CBV decrease in the NAc, while other brain regions show a slow CBV increase comparable to the temporal dynamic of opioid receptor binding.

This abstract and the presentation materials are available to members only; a login is required.

Join Here