Abstract #0371
Advanced Assessment of Liver Diseases with Magnetic Resonance Elastography in Mouse Models
Meng Yin 1 , Douglas A. Simonetto 2 , Jason L. Bakeberg 3 , Anuradha Krishnan 2 , Kevin J. Glaser 1 , Vijay H. Shah 2 , Christopher J. Ward 3 , Peter C. Harris 3 , Michael R. Charlton 2 , Armando Manduca 1 , and Richard L. Ehman 1
1
Radiology, Mayo Clinic, Rochester,
Minnesota, United States,
2
Gastroenterology
and Hepatology, Mayo Clinic, Rochester, Minnesota,
United States,
3
Nephrology and Hypertension,
Mayo Clinic, Rochester, Minnesota, United States
To investigate the utility of MRE-derived mechanical
properties in characterizing diseased hepatic tissue, we
performed multifrequency 3-D/3-axis MRE on three
different mouse models with chronic liver diseases that
involved varying degrees of hepatic inflammation,
fibrosis, congestion and portal hypertension. Results
demonstrated systematic variations in mechanical
properties with hepatic inflammation, fibrosis and
increased portal pressure. The findings offer
preliminary evidence of the potential to extend MRE to
distinguish and independently assess necroinflammatory,
congestive, and fibrotic processes.
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