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Abstract #0363

Diffusion tensor and magnetization transfer imaging of tumor margin in a rat C6 Glioma Model

Monika Huhndorf 1 , Olga Will 2 , Rolf Mentlein 3 , Olav Jansen 1 , and Susann Boretius 2

1 Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein, Kiel, Germany, 2 Section Biomedical Imaging, Department of Radiology and Neuroradiology, Christian-Albrechts-University, Kiel, Germany, 3 Anatomical Institute, Christian-Albrechts-University, Kiel, Germany

Glioblastoma multiforme is the most malignant brain tumor with an infaust prognosis and still a therapeutic challenge, because of its infiltrative tumor growth. Visualizing tumor-cell infiltration non-invasively has been focused by many scientists. Since infiltration starts at the tumor margin, we focused on imaging of this area in a rat C6-glioma model at 7T MRI using diffusion tensor and magnetization transfer imaging. We observed an increase in fractional anisotropy and MT saturation at the tumor margin beyond the tumor region visible on T2-weighted images indicating structural changes in peritumoral tissue.

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