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Abstract #0356

Effect of chronic administration of -hydroxybutyrate in spontaneously epileptic kcna1-null mice measured with Manganese Enhanced MRI (MEMRI)

Gregory Harrison Turner 1 , Johana Vallejo 2 , Mohammed Abdelwahab 3 , Qingwei Liu 1 , Lana Leung 2 , Younghee Ahn 4 , Jong Rho 4 , and Do Young Kim 3

1 Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, 2 Physiology, Midwestern University, Glendale, AZ, United States, 3 Barrow Neurological Institute, AZ, United States, 4 Alberta Children's Hospital, University of Calgary, Alberta, Canada

Chronic in vivo administration of BHB results in a significant anticonvulsant effect in Kcna1-null mice. Moreover, Manganese Enhanced MRI found that BHB alone appears to exert a structural neuroprotective effect in hippocampus. The combination of morphological and functional neuroprotective effects of BHB in this genetic model of epilepsy suggests that KB may be beneficial for neurological conditions other than epilepsy.

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