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Abstract #0337

An Improved Gradient Echo Myelin Water Imaging using a Frequency Offset Model and Early Echoes

Yoonho Nam 1 , Jongho Lee 2 , Dosik Hwang 1 , and Dong-Hyun Kim 1

1 Department of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea, 2 Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States

Myelin water imaging has been proposed as a potential biomarker for demyelinating diseases. In this study, we demonstrated that the multi-component model with frequency offsets offers substantially reliable MWF results that are less affected by the number of echoes used in the analysis. Additionally, we revealed that the MWF map generated from early echoes is less sensitive to B0 field inhomogeneity and, hence, provides wider brain coverage. Lastly, we performed a test-retest scan and demonstrated that the frequency offset model with early echoes provides more reproducible results.

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