Abstract #0288
An in-vivo 1H MRS study of metabolic correlation in IDH1 vs. IDH2 mutated gliomas
Changho Choi 1 , Sandeep Ganji 1 , Akshay Madan 1 , Zhongxu An 1 , and Elizabeth Maher 1
1
UT Southwestern Medical Center, Dallas,
Texas, United States
Isocitrate dehydrogenases (IDH) 1 and 2 catalyze the
NADP+ dependent conversion of isocitrate to
-ketoglutarate in the cytosol and mitochondria,
respectively. The mutations in these enzymes result in
the production of 2-hydroxyglutarate (2HG). We have
investigated metabolic correlations in IDH1- vs.
IDH2-mutated gliomas (28 and 5 patients, respectively)
focusing on 2HG in vivo, using 1H MRS at 3T. Data
indicated 2HG levels were highly correlated with choline,
NAA, creatine and glutamate. The correlations were
stronger in IDH2 mutated gliomas than in IDH1 mutated
gliomas.
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