Abstract #0281
Identification of Arterio-Venous Shunts by Vessel Architectural Imaging Reveals Mechanisms of Vascular Normalization during Anti-Angiogenic Therapy
Guro K. Rognsvag 1 , Atle Bjornerud 1,2 , A. Gregory Sorensen 3,4 , Patrick Y. Wen 5 , Tracy T. Batchelor 6,7 , Rakesh K. Jain 6 , and Kyrre E. Emblem 1,3
1
The Intervention Centre, Oslo University
Hospital, Oslo, Oslo, Norway,
2
Dept
of Physics, University of Oslo, Oslo, Norway,
3
Department
of Radiology and Athinoula A. Martinos Center for
Biomedical Imaging, Massachusetts General Hospital and
Harvard Medical School, Boston, MA, United States,
4
Siemens
Healthcare, Malvern, PA, United States,
5
Center
for Neuro-Oncology, Dana-Farber/Brigham and Women's
Cancer Center and Harvard Medical School, Boston, MA,
United States,
6
Department
of Radiation Oncology, Massachusetts General Hospital
and Harvard Medical School, Boston, MA, United States,
7
Department
of Neurology, Massachusetts General Hospital and Harvard
Medical School, Boston, MA, United States
The microvasculature of tumors is abnormal and tortuous
with arterio-venous shunts. Shunts are short high-flow
vascular pathways that cause parts of the blood flow to
bypass capillary regions, thus impairing delivery of
oxygen to the tissue and increasing resistance to
therapy. Vessel architectural imaging (VAI) has recently
been introduced as a new paradigm for in vivo assessment
of cancer vasculature. By performing Monte Carlo
simulations of normal and shunting tissue, and
evaluating MRI data of patients undergoing anti-angiogenic
therapy, we show that VAI identifies arterio-venous
shunts and help reveal mechanism of normalization during
anti-angiogenic therapy.
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