Abstract #0253
Demonstration of Differentially Degenerated Corpus Callosam in Patients with Moderate Traumatic Brain Injury: With a Premise of Cortical-callosal Relationship
Kavita Singh 1 , Richa Trivedi 1 , Maria M Dsouza 1 , Ajay Chaudhary 2 , Pawan Kumar 1 , Ram KS Rathore 3 , Rajendra P Tripathi 1 , and Subash Khushu 1
1
Institute of Nuclear Medicine & Allied
Sciences, Delhi, Delhi, India,
2
Dr.
Ram Manohar Lohia Hospital, Delhi, Delhi, Delhi, India,
3
Indian
Institute of Technology, Kanpur, Kanpur, Uttar Pradesh,
India
Aim our study was to assess the degenerative changes,
secondary to TBI in subdivisional fibres of CC,
corresponding to cortical brain area primarily injured
in chronic moderate TBI patients. DTT was done in 18 TBI
(A: frontal lobe injury,n=6; B: occipito-temporal lobe
injury, n=5; C: fronto-parieto-temporal lobe injury,
n=7) and 11 healthy participants. Diffusion metrices of
7 sub-divisions of CC (Witelsons scheme) were acquired
using in-house developed software. The study showed
significantly reduced FA and increased MD in the
sub-divisions of CC corresponding to cortical brain area
primarily injured. Reduced FA and increased MD values
may represent regional Wallerian Degeneration.
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