Abstract #0243
Quantification of Energy Loss in Hypertrophic Cardiomyopathy using 4D Flow MRI
Carla Contaldi 1 , Pim van Ooij 2 , Bradley Allen 2 , Julio Garcia 2 , Jeremy Collins 2 , James Carr 3 , Daniel C. Lee 4 , Brandon Benefield 2 , Lubna Choudhury 1 , Michael Markl 5 , Alex J. Barker 2 , and Robert O. Bonow 1
1
Department of Medicine Cardiology,
Northwestern University Feinberg School of Medicine,
Chicago, IL, Chicago, Illinois, United States,
2
Radiology,
Northwestern University Feinberg School of Medicine,
Chicago, IL, Chicago, Illinois, United States,
3
Radiology
and Medicine, Northwestern University Feinberg School of
Medicine, Chicago, IL, Chicago, Illinois, United States,
4
Department
of Medicine Cardiology and Radiology, Northwestern
University Feinberg School of Medicine, Chicago, IL,
Chicago, Illinois, United States,
5
Radiology
and Biomedical Engineering, Northwestern University
Feinberg School of Medicine, Chicago, IL, Chicago,
Illinois, United States
The aim of this study was to characterize obstructive
hypertrophic cardiomyopathy (HCM) severity by
irreversible energy loss, caused by viscous dissipation,
and calculated from 4D Flow MRI velocity fields covering
the entire left ventricular outflow tract (LVOT). The
difference in energy loss between HCM patients and
controls was significant. Energy loss showed a strong
correlation with LVOT gradient calculated from 4D Flow
MRI and a good correlation with myocardial fibrosis as
quantified by extracellular volume fraction by T1
mapping MRI. Elevated energy loss may indicate increased
hemodynamic loading and left ventricular remodeling and
may be useful in HCM severity assessment.
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