Abstract #0239
Detection of Infarcted and Arrhythmogenic Myocardium with DTI Tractography and Electroanatomical Voltage Mapping
Choukri Mekkaoui 1 , Marcel P Jackowski 2 , Christian T Stoeck 3 , Aravinda Thiagalingam 4 , William J Kostis 5 , Jeremy N Ruskin 5 , Timothy G Reese 6 , Sebastian Kozerke 7 , and David E Sosnovik 8
1
Harvard Medical School - Massachusetts
General Hospital, Boston, MA, United States,
2
Department
of Computer Science, Institute of Mathematics and
Statistics, University of So Paulo, So Paulo, Brazil,
3
Institute
for Biomedical Engineering, University and ETH Zurich,
Zurich, Switzerland,
4
University of Sydney,
Sydney, Australia,
5
Massachusetts
General Hospital, Boston, United States,
6
Athinoula
A Martinos center for Biomedical imaging, Boston, United
States,
7
University
and ETH Zurich, Zurich, Switzerland,
8
Harvard
Medical School - Massachusetts General Hospital, Boston,
United States
The tractographic propagation angle (PA) is a
topographic measure of myocardial fiber architecture.
Here, we demonstrate the correlation of PA with late
gadolinium enhancement and electroanatomical voltage
mapping in the detection of infarcted myocardium (PA>4
o
),
as well as its ability to delineate regions of
heterogeneous scar (4
o
≤PA≤10
o
) and
dense scar (PA>10
o
). PA detects infarction
and defines the substrate for reentrant ventricular
arrhythmias without the need for exogenous contrast
agents. PA could become a valuable tool in
cardiovascular imaging, especially among patients with
renal dysfunction and those at risk of sudden cardiac
death.
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