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Abstract #0226

Glutamate and GABA in Children with ADHD and Complex Motor Stereotypies: A 7T H MRS Study

Alena Horska 1 , Xin Wang 1 , Matthew Ryan 2 , Martha B Denckla 2 , Peter B Barker 1 , Harvey S Singer 1 , and E Mark Mahone 2

1 Johns Hopkins University, Baltimore, MD, United States, 2 Kennedy Krieger Institute, Baltimore, MD, United States

Using single voxel H MRS at 7T, concentrations of the neurotransmitters glutamate (Glu) and GABA were measured in prefrontal and fronto-striatal regions in pediatric patients 5-10 years old, diagnosed with ADHD and complex motor stereotypies (CMS). The control group was comprised of age-matched healthy typically developing children. Compared with controls, both patient groups had a lower overall mean GABA/Cr ratio (calculated from the 4 regions examined) and a lower striatal GABA/Cr ratio. No group differences in the GABA/Cr and NAA/Cr ratios were detected.

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