Pharmacokinetic Analysis for Differentiating Benign and Malignant Spinal Tumors Measured by DCE-MRI
Ning Lang 1 , Min-Ying Lydia Su 2 , Hon J Yu 2 , and Huishu Yuan 1
Department of Radiology, Peking University
Third Hospital, Beijing, China,
& Yuen Center for Functional Onco-Imaging, Department of
Radiological Sciences, University of California, Irvine,
CA, United States
DCE-MRI was performed to differentiate 4 spinal lesions
(9 myeloma, 22 metastatic cancer, 7 lymphoma, 22 benign
tuberculosis). The peak signal enhancement, the steepest
wash-in slope and wash-out slope were measured.
Two-compartmental pharmacokinetic model was used to
obtain Ktrans and kep, by using three different blood
curves (fast, medium, and slow). The results showed that
kep analyzed by using fast or medium blood curves is the
best parameter to differentiate these 4 lesion groups.
Ktrans is associated with wash-in slope and kep is
associated with wash-out slope. The slow blood curve is
not suitable for a short DCE period.
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