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Abstract #0213

The Dependency of Cerebral Blood Flow on End-tidal CO 2 Pressure

Eidrees Ghariq 1 , Xingxing Zhang 1 , Andrew G. Webb 1 , Mark A. Van Buchem 1 , Albert Dahan 2 , and Matthias J.P. Van Osch 1

1 C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center (LUMC), Leiden, Zuid-Holland, Netherlands, 2 Deparment of Anesthesiology, Leiden University Medical Center (LUMC), Leiden, Zuid-Holland, Netherlands

Regional cerebrovascular reactivity (CVR) to CO2 is increasingly measured with BOLD and ASL MRI. The data processing is based on the assumption of a linear relationship between BOLD/CBF and CO2. However, we show that the BOLD CO2 reactivity curve has a sigmoidal shape, but the CBF-CO2 relationship is linear in the CO2 range of 3 kPa to 8 kPa. These findings underline a cautious approach to interpreting the CO2 CVR data measured with BOLD and support the conclusion that CBF is a more robust tool for CO2 CVR measurements.

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