Abstract #0213
The Dependency of Cerebral Blood Flow on End-tidal CO 2 Pressure
Eidrees Ghariq 1 , Xingxing Zhang 1 , Andrew G. Webb 1 , Mark A. Van Buchem 1 , Albert Dahan 2 , and Matthias J.P. Van Osch 1
1
C.J. Gorter Center for High Field MRI,
Department of Radiology, Leiden University Medical
Center (LUMC), Leiden, Zuid-Holland, Netherlands,
2
Deparment
of Anesthesiology, Leiden University Medical Center (LUMC),
Leiden, Zuid-Holland, Netherlands
Regional cerebrovascular reactivity (CVR) to CO2 is
increasingly measured with BOLD and ASL MRI. The data
processing is based on the assumption of a linear
relationship between BOLD/CBF and CO2. However, we show
that the BOLD CO2 reactivity curve has a sigmoidal
shape, but the CBF-CO2 relationship is linear in the CO2
range of 3 kPa to 8 kPa. These findings underline a
cautious approach to interpreting the CO2 CVR data
measured with BOLD and support the conclusion that CBF
is a more robust tool for CO2 CVR measurements.
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