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Abstract #0208

High-resolution quantitative magnetization transfer imaging of post-mortem marmoset brain

Henrik Marschner 1 , Andr Pampel 1 , Roland Mller 1 , Nicholas A. Bock 2 , Marcel Weiss 1,3 , Stefan Geyer 1 , and Harald E. Mller 1

1 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Saxony, Germany, 2 McMaster University, Ontario, Canada, 3 University of Amsterdam, North Holland, Netherlands

We present results of quantitative magnetization transfer imaging (qMTI) in high resolution for quantification of (qMT) parameters of otherwise MR-invisible macromolecules. qMTI was performed on a post-mortem marmoset brain at 3T and the results are compared to T1 mapping results obtained at 7T. The high resolution of 200 m permits visualization of cortical substructures in the marmoset brain, as presented for the stria of Gennari. An analysis of correlation between the macromolecular pool-size fraction and T1 shows different linear regressions in white and gray matter. This suggests i) different myelination contribution in both contrast parameters, or ii) other contributing factors.

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