Abstract #0198
MR Molecular Imaging of Breast Cancer Metastases with Peptide Targeted Tripod Macrocyclic Gd(III) Chelates
Zhuxian Zhou 1 , Mohammed Qutaish 1 , David L. Wilson 1 , and Zheng-Rong Lu 1
1
Biomedical Engineering, Case Western Reserve
University, Cleveland, OH, United States
MRI is a powerful medical imaging modality for the
detection and characterization of diseased soft tissues
such as solid tumors. MR molecular imaging has a great
potential for detection and characterization of
metastatic breast cancer if a suitable molecular target
can be identified. However, currently available targeted
contrast agents could not generate sufficient contrast
enhancement for molecular MRI of the biomarkers on
cancer cell surface due to low concentration of the
biomarkers and low sensitivity of MRI. The extracellular
matrix of malignant tumors has abundant accumulation of
fibrin-fibronectin complexes that can be used as a
suitable biomarker for effective molecular MRI of small
breast cancer metastases. CREKA is a tumor-homing
pentapeptide (Cys-Arg-Glu-Lys-Ala) specifically homes to
tumors by binding to fibrin and fibronectin associated
plasma protein clots in tumor stroma. Here, we
synthesized and evaluated a tumor-targeted contrast
agent CREKA-Tris(Gd-DOTA)3 for MR molecular imaging of
breast cancer metastases.
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