Abstract #0182
Correlation between cardiovascular T1 MRI, histology and future ventricular remodeling in ischemic heart disease.
Walter RT Witschey 1 , Jeremy R McGarvey 1 , Madonna Lee 1 , Francisco Contijoch 2 , Victor Ferrari 3 , Yuchi Han 3 , Julio A Chirinos 3 , Chikashi Aoki 1 , Satoshi Takebayashi 4 , Joseph H Gorman III 1 , James J Pilla 4 , and Robert C Gorman 1
1
Surgery, University of Pennsylvania,
Philadelphia, PA, United States,
2
Bioengineering,
University of Pennsylvania, Philadelphia, PA, United
States,
3
Cardiology, University of
Pennsylvania, Philadelphia, PA, United States,
4
Radiology,
University of Pennsylvania, Philadelphia, PA, United
States
T1rho MRI has been shown to detect myocardial fibrosis
and has potential to be used as a biomarker for heart
disease. The progression of T1rho relaxation times in
inflammation, wound healing and scar have been reported
for direct ligation animal models, mimicking only the
most severe types of human ischemic heart disease. Our
objective was to determine the relationship between
T1rho relaxation times and pathology, at 1 day, 1 and 4
weeks post-infarction in an ischemia-reperfusion pig
model. We found that there was a significant increase in
T1rho relaxation times at 1 week in pigs and this was
indicative of future ventricular remodeling. There was
excellent correlation between T1rho MRI-determined
infarction area, coronary artery perfusion watershed and
fibrosis.
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