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Abstract #0166

BOLD Alterations in Schizophrenia: Spectral Changes in Resting-state fMRI Signal

Chen-Yuan Kuo 1 , Tsuo-Hung Lan 1 , Changwei W. Wu 2 , Kun-Hsien Chou 3 , Chun-Yi Lo 3 , and Ching-Po Lin 3

1 Institution of Brain Science, National Yang-Ming University, Taipei, Taiwan, 2 Graduate Institute of Biomedical Engineering, National Central University, Taoyuan, Taiwan, 3 Institution of Neuroscience, National Yang-Ming University, Taipei, Taiwan

Schizophrenia is a complex mental illness, including the disorganize of thinking, behavior, and cognition. Recent study showed that functional abnormality of thalamus could be one of the underlying mechanisms in schizophrenia, and such conjecture can be further investigated using the resting-state fMRI technique. In this project, we examined the spectral distributions in the resting-state fMRI signals and conducted the comparison between schizophrenia patients and normal control. We discovered that spectral specificity exhibited in low-frequency oscillations of thalamus between the two groups, providing further evidence to study the functional alterations in schizophrenia.

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