Abstract #0166
BOLD Alterations in Schizophrenia: Spectral Changes in Resting-state fMRI Signal
Chen-Yuan Kuo 1 , Tsuo-Hung Lan 1 , Changwei W. Wu 2 , Kun-Hsien Chou 3 , Chun-Yi Lo 3 , and Ching-Po Lin 3
1
Institution of Brain Science, National
Yang-Ming University, Taipei, Taiwan,
2
Graduate
Institute of Biomedical Engineering, National Central
University, Taoyuan, Taiwan,
3
Institution
of Neuroscience, National Yang-Ming University, Taipei,
Taiwan
Schizophrenia is a complex mental illness, including the
disorganize of thinking, behavior, and cognition. Recent
study showed that functional abnormality of thalamus
could be one of the underlying mechanisms in
schizophrenia, and such conjecture can be further
investigated using the resting-state fMRI technique. In
this project, we examined the spectral distributions in
the resting-state fMRI signals and conducted the
comparison between schizophrenia patients and normal
control. We discovered that spectral specificity
exhibited in low-frequency oscillations of thalamus
between the two groups, providing further evidence to
study the functional alterations in schizophrenia.
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