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Abstract #0145

Poor Gadoxetate Disodium Hepatobiliary Enhancement in MRI of Patients with Cirrhosis: Factors for Prediction

Amelia Wnorowski 1 , Flavius Guglielmo 1 , Laurence Parker 1 , Sandeep Deshmukh 1 , Patrick O'Kane 1 , Christopher Roth 1 , and Donald Mitchell 1

1 Radiology, Thomas Jefferson University Hospital, Philadelphia, PA, United States

Gadoxetate disodium is a useful MRI contrast agent for the diagnosis of hepatocellular carcinoma in cirrhosis. Its use is limited by poor hepatic and biliary enhancement in some patients. The purpose of this study was to identify predictors of poor enhancement, which was assessed in 91 cirrhotic patients and compared to various laboratory parameters, liver length and degree of ascites. A correlation matrix was performed, followed by multiple and logistic regressions. Several variables independently correlated with enhancement. However, the first variable chosen, either albumin or MELD score, accounted for almost all of the variance in the model.

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