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Abstract #0137

Hyperpolarized [1,3- 13 C 2 ]ethyl acetoacetate is a novel diagnostic metabolic marker of liver cancer.

Sonia Colombo Serra 1 , Pernille Rose Jensen 2 , Luigi Miragoli 1 , Magnus Karlsson 2 , Claudia Cabella 1 , Luisa Poggi 1 , Luca Venturi 3 , Fabio Tedoldi 1 , and Mathilde Lerche 2

1 Centro Ricerche Bracco, Bracco Imaging SpA, Colleretto Giacosa, Torino, Italy, 2 Albeda Research, Copenhagen, Copenhagen, Denmark, 3 CEIP, University of Torino, Colleretto Giacosa, Torino, Italy

Hepatocellular carcinoma (HCC) is most often found in cirrhotic livers and can be hardly diagnosed relying on anatomical information alone. Magnetic resonance is commonly used to identify anatomical lesions, but can also provide information on cellular metabolism by an emerging method that uses 13 C labeled hyperpolarized molecules. This study aimed at probing the potential of hyperpolarized [1,3- 13 C 2 ]ethyl acetoacetate as a metabolic marker of HCC. A liver cancer implanted in rats is diagnosed due to a higher substrate-to-product ratio in tumors than in healthy livers demonstrating that the metabolism of the liver isoform of carboxyl esterase can be monitored in vivo .

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