Abstract #0135
LONGITUDINAL ANALYSIS OF BRAIN NETWORK REORGANIZATION IN PRETERM IUGR CHILDREN AT 1, 6 AND 9 YEARS OF AGE
Emma Muoz-Moreno 1 , Elda Fischi-Gomez 2,3 , Dafnis Batalle 1 , Lana Vasung 3 , Elisenda Eixarch 1,4 , Jean-Philippe Thiran 2,5 , Eduard Gratacos 1,4 , and Petra Susan Huppi 3
1
Fetal and Perinatal Medicine Research Group,
IDIBAPS, Barcelona, Spain,
2
Signal
Processing Laboratory 5 (LTS5), Ecole Polytechnique
Fdrale de Lausanne, Lausanne, Switzerland,
3
Division
of Development and Growth. Department of Pediatrics,
University of Geneva, Geneva, Switzerland,
4
Maternal-Fetal
Medicine Department, ICGON, Hospital Clnic, Universitat
de Barcelona, Barcelona, Spain,
5
Department
of Radiology, University Hospital Center (CHUV) and
University of Lausanne (UNIL), Lausanne, Switzerland
Intrauterine Growth Restriction (IUGR) due to placental
insufficiency is associated with short and long-term
neurodevelopmental disorders. In this study, connectomic
analysis based on diffusion magnetic resonance (dMRI)
was performed in cohorts of 1-, 6- and 9-year-old
children that were born preterm. Two groups were
considered at each age, children with normal growth and
children with IUGR. Tractography was used to infer the
connections between brain regions, and estimate the
connectome matrix of each subject, and graph measures
were computed. Results showed that a pattern of
alterations in graph measures describing brain
organization in IUGR persists along childhood.
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