Abstract #0127
ASSESMENT OF LATE-ONSET IUGR IN THE FETAL BRAIN USING 1H-MRS
Rui Vasco Simoes 1 , Magdalena Sanz-Cortes 1 , Nuria Bargallo 2 , Francesc Figueras 1 , and Eduard Gratacos 1
1
Dept of Maternal-Fetal Medicine, Hospital
Clinic, Barcelona, Barcelona, Spain,
2
Dept
of Radiology, Hospital Clinic, Barcelona, Barcelona,
Spain
Intrauterine growth restriction (IUGR) is associated
with impaired neurodevelopment. Late-onset IUGR cases
are particularly difficult to diagnose in the clinic and
the metabolic changes underlying their long-term brain
dysfunctions remain poorly understood. We show that the
NAA/Cho ratio (LCModel) is significantly lower in
late-onset IUGR fetuses than in age-matched controls,
independent of clinical risk factors. Our preliminary
MRS pattern classification results (SpectraClassifier)
suggest the existence of metabolic signatures for each
group: control, IUGR without risk factors, and IUGR with
risk factors. Further work will validate these results
with a follow-up study in a larger population cohort.
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