Abstract #0123
Region-specific microstructure of cortical areas revealed with high angular resolution diffusion MR microimaging
Manisha Aggarwal 1 , Olga Pletnikova 2 , Juan Troncoso 2 , and Susumu Mori 1
1
Department of Radiology, Johns Hopkins
University School of Medicine, Baltimore, MD, United
States,
2
Department
of Pathology, Johns Hopkins University School of
Medicine, Baltimore, MD, United States
We demonstrate high angular resolution diffusion MR
microimaging to resolve the region-specific
microstructure of cortical areas in the fixed human
brain. Diffusion MRI of cortical tissue microstructure
is challenged by both the low anisotropy in gray matter
microenvironments and the level of resolution necessary
to delineate the layered architecture. Here, using 3D
gradient and spin echo based acquisition, HARDI data of
cortical specimens were acquired with 30 diffusion
directions at 90 m isotropic resolution. The diffusion
micro-imaging data of the prefrontal, primary motor, and
primary visual areas revealed the region-specific
laminar microstructure of cortical gray matter with
unprecedented detail.
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