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Abstract #0111

In vivo quantification of lipid-rich necrotic core using contrast-enhanced three-dimensional vessel wall imaging

Jie Sun 1 , Niranjan Balu 1 , Kiyofumi Yamada 1 , Jinnan Wang 2 , Daniel S. Hippe 1 , Dongxiang Xu 1 , Thomas S. Hatsukami 1 , and Chun Yuan 1

1 University of Washington, Seattle, WA, United States, 2 Philips Research North America, Briarcliff Manor, NY, United States

In vivo quantification of lipid-rich necrotic core size not only reveals prognostic information on patients atherothrombotic risk, but also provides a novel means for understanding effects of risk factors on plaque progression. Although a 2D multi-contrast protocol is traditionally used for classifying LRNC areas in advanced plaques, recently developed 3D sequences offer the opportunity to move LRNC quantification from 2D to 3D. This report represents one of the first studies to evaluate the performance of 3D MRI with contrast-enhanced imaging in delineating LRNC areas, which showed good agreement with a histologically validated 2D multi-contrast protocol across various lesion complexities.

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