Abstract #0098
Diffusion MRI with q-vector magic angle spinning (qMAS) disentangles effects of micro-anisotropy and orientation dispersion
Filip Szczepankiewicz 1 , Samo Lasic 2 , Jimmy Ltt 3 , Danielle van Westen 4 , Carl-Fredrik Westin 5 , Freddy Sthlberg 1,4 , Daniel Topgaard 6 , and Markus Nilsson 7
1
Department of Medical Radiation Physics,
Lund University, Lund, Sweden,
2
CR
Development, AB, Lund, Sweden,
3
Center
for Medical Imaging and Physiology, Skane University
Hospital, Lund, Sweden,
4
Department
of Diagnostic Radiology, Skane University Hospital,
Lund, Sweden,
5
Laboratory
of Mathematics in Imaging, Harvard Medical School,
Boston, MA, United States,
6
Center
for Chemistry and Chemical Engineering, Lund University,
Lund, Sweden,
7
Lund
University Bioimaging Center, Lund University, Lund,
Sweden
In this work we present the first in vivo experiments
employing magic angle spinning of the q-vector (qMAS) to
map the microscopic anisotropy of the brain. This
technique allows for the parameterization of anisotropy
that is unaffected by the orientation dispersion. This
means that the anisotropy is probed on a sub-voxel
scale, and can potentially be useful in complex white
matter geometries and gray matter, where conventional
metrics such as FA are confounded by the tissue micro
architecture.
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