Abstract #0075
Molecular MRI detection of the brain development in normal children with magnetization transfer (MT) and amide proton transfer (APT) imaging
Hong Zhang 1,2 , Xuna Zhao 3 , Jinyuan Zhou 2 , and Yun Peng 4
1
Imaging Center,Beijing Childrens Hospital,
Capital Medical University, Beijing, China,
2
Neurosection,
Division of MR Research, Department of Radiology, Johns
Hopkins University, Baltimore, MD, United States,
3
Peking
University, Beijing, China,
4
Beijing
Childrens Hospital, Capital Medical University,
Beijing, China
MT-MRI is sensitive to a semi-solid macromolecular phase
in tissue, and APT-MRI is sensitive to the amide protons
of mobile proteins and peptides, both accomplishing
detection using the water signal. We detected brain
development patterns in normal children using MT and APT
imaging at 3T. Our preliminary results showed that
MTRasym(3.5ppm) decreased exponentially and MTR
increased exponentially with age, with the most
significant changes occurring within the first 2 years
of life. MT and APT imaging may be useful to assess the
progress of myelination.
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