Abstract #0071
Assessment of Macromolecular and Metabolic Alterations during Normal Brain Aging in the Dark Agouti Rat using 1H MRS at 17.2 Tesla
Alfredo Liubomir Lopez Kolkovsky 1 , Boucif Djemai 1 , and Fawzi Boumezbeur 1
1
CEA/Saclay/Neurospin, Commissariat a
l'Energie Atomique, Gif-sur-yvette, Essonne, France
Normal brain aging is usually associated with a decline
in brain function. Yet, the neural basis of age-related
cognitive dysfunction in normal brain aging remains to
be entirely elucidated. In this study, we sought to
explore further these metabolic alterations in the brain
of healthy rats with in vivo short echo time
1
H
MRS at 17.2 T. Comparing metabolic profiles from young
and elderly rats (1 and 16 months old respectively), it
was found a decrease in neurotransmitters (Gln+Glu,
GABA) and increase in Ins and tCho consistent with
decline of neural function and chronic low-level glial
activation consistent with previous observations in
humans.
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